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Volume 33 , Issue 5
September/October 2013
Pages 641–649

Effects of Enamel Matrix Derivative and Basic Fibroblast Growth Factor with β–Tricalcium Phosphate on Periodontal Regeneration in One-Wall Intrabony Defects: An Experimental Study in Dogs

Yoshinori Shirakata, DDS, PhD/Naoshi Takeuchi, DDS/Takehiko Yoshimoto, DDS, PhD/Katsuyoshi Taniyama, DDS/Kazuyuki Noguchi, DDS, PhD

PMID: 23998160
DOI: 10.11607/prd.0989

This study evaluated the effects of enamel matrix derivative (EMD) and basic fibroblast growth factor (bFGF) with β–tricalcium phosphate (β-TCP) on periodontal healing in intrabony defects in dogs. One-wall intrabony defects created in dogs were treated with β-TCP alone (β-TCP), EMD with β-TCP (EMD/β-TCP), bFGF with β-TCP (bFGF/β-TCP), and a combination of each (EMD/bFGF/β-TCP). The amount of new bone formation was not significant for any group. The EMD/bFGF/β-TCP group induced significantly greater new cementum formation than the β-TCP and bFGF/β-TCP groups and, although not significantly, formed more new cementum than the EMD/β-TCP group. These findings indicate that EMD/bFGF/β-TCP treatment is effective for cementum regeneration. (Int J Periodontics Restorative Dent 2013;33: 641–649. doi: 10.11607/prd.0989)

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